cis-Urocanic acid

CAS No. 7699-35-6

cis-Urocanic acid( (Z)-Urocanic acid | cis-UCA | (E)-Urocanic acid | (Z)-Imidazole-4-acrylic acid | (Z)-3-(1H-Imidazol-5-yl)acrylic acid )

Catalog No. M26118 CAS No. 7699-35-6

cis-Urocanic acid is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    cis-Urocanic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    cis-Urocanic acid is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.
  • Description
    cis-Urocanic acid is a 5-HT2A receptor agonist (Kd: 4.6 nM). It is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.(In Vitro):Treatment with 100 μg/mL cis-Urocanic acid completely suppresses IL-6 and IL-8 secretion decreases caspase-3 activity and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types .
  • In Vitro
    Treatment with 100 μg/mL cis-Urocanic acid (cis-UCA) completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells are observed with 100 μg/mL cis-Urocanic acid in both cell types. The 5000 μg/mL concentration is toxic Cell Viability Assay Cell Line:Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs)Concentration:10, 100, 1,000, and 5,000 μg/mL Incubation Time:24, 48, or 72 hours Result:Treatment with 100 μg/mL completely suppressed IL-6 and IL-8 secretion, decreased caspase-3 activity, and improved cell viability against UV-B irradiation. No significant effects on IL-6 or IL-8 secretion, caspase-3 activity, or viability of the non-irradiated cells were observed with 100 μg/mL in both cell types.
  • In Vivo
    ——
  • Synonyms
    (Z)-Urocanic acid | cis-UCA | (E)-Urocanic acid | (Z)-Imidazole-4-acrylic acid | (Z)-3-(1H-Imidazol-5-yl)acrylic acid
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    Alkyl-Chain
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    7699-35-6
  • Formula Weight
    138.126
  • Molecular Formula
    C6H6N2O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (362.00 mM)
  • SMILES
    OC(=O)\C=C/c1cnc[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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